Evaluation of Hepatoprotective activity of Ethanolic Extract of Nymphaea alba Linn Flower in experimental rats

International Journal of Biomedical Research

Ashish K. Paharia¹  A. Pandurangan² 

[1] Department of Pharmaceutical Science, Shri Venkateshwara University, Gajraula (U.P.).;M. M. College of Pharmacy, MM University Mullana (Ambala) Haryana

关键词: Hepatoprotective activity;    Nymphaea alba Linn;    Carbon Tetra Chloride;    Paracetamol induced hepatotoxicity;   

DOI  :  10.7439/ijbr.v4i7.326

学科分类：基础医学

来源: Scholar Science Journals

【 摘 要 】

Objective: In the present study Hepatoprotective activity of Ethanolic Extract of flower of Nymphaea alba Linn were investigated.Material & Method: The hepatoprotective activity of Ethanolic Extract of flower of Nymphaea alba were evaluated by Carbon Tetra Chloride & Paracetamol induced hepatotoxicity in experimental rats. The Etnanolic Extract of Nymphaea alba (200 & 400 mg/kg) treat the hepatotoxicity and produced significant inhibition in the wet liver weight and wet liver volumes and the serum enzymes (SGOT, SGPT & ALP), bilirubin and cholesterol levels.Result: Preliminary phytochemical analysis of Ethanolic Extract of Nymphaea alba revealed that the presence of various phytoconstituents Alkaloids, Carbohydrates (Polysaccharides), Glycosides, Steroids, Flavonoids and Tannin & Phenolic compound. The ethanolic extract (200 & 400 mg/kg) showed significant reduction in SGOT, SGPT, ALP, Bilirubin & cholesterol level as compared to control group. Maximum inhibition was obtained at dose 400 mg/kg of Ethanolic Extract of Nymphaea alba in both model.Conclusion: The present study suggests that Ethanolic Extract of flower of Nymphaea alba Linn possess strong and potential Hepatoprotective activity in both model. So it has immense scope as an effective source to develop drug for the treatment of liver related diseases. These results may further suggest that ethanolic extract was found to possess hepatoprotective activity.

【 授权许可】

CC BY