Critical Loss of the Balance between Th17 and T Regulatory Cell Populations in Pathogenic SIV Infection

PLoS Pathogens

Sean Proll¹  Joseph M. McCune¹  Bittoo Kanwar²  David Favre²  Jeff Mold²  Louise Swainson²  Jason D. Barbour²  Carole R. Baskin³  Robert Palermo⁴  Zeljka Kasakow⁴  Christopher J. Miller⁴  Sharon Lederer⁴  Zhong-Min Ma⁵  Michael G. Katze⁶  Ivona Pandrea⁷ 

[1] Center for Comparative Medicine, California National Primate Research Center, University of California, Davis, California, United States of America;Department of Medicine, Division of Experimental Medicine, University of California, San Francisco, California, United States of America;Department of Medicine, HIV/AIDS Division, University of California, San Francisco, California, United States of America;Department of Microbiology, University of Washington, Seattle, Washington, United States of America;Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of California, San Francisco, California, United States of America;Tulane National Primate Research Center, Covington, Louisiana, United States of America;Washington National Primate Research Center, University of Washington, Seattle, Washington, United States of America

关键词: T cells;    Colon;    Regulatory T cells;    Immune activation;    Lymph nodes;    SIV;    Blood;    Cytokines;   

DOI  :  10.1371/journal.ppat.1000295

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Chronic immune activation and progression to AIDS are observed after SIV infection in macaques but not in natural host primate species. To better understand this dichotomy, we compared acute pathogenic SIV infection in pigtailed macaques (PTs) to non-pathogenic infection in African green monkeys (AGMs). SIVagm-infected PTs, but not SIVagm-infected AGMs, rapidly developed systemic immune activation, marked and selective depletion of IL-17-secreting (Th17) cells, and loss of the balance between Th17 and T regulatory (Treg) cells in blood, lymphoid organs, and mucosal tissue. The loss of Th17 cells was found to be predictive of systemic and sustained T cell activation. Collectively, these data indicate that loss of the Th17 to Treg balance is related to SIV disease progression.

【 授权许可】

CC BY