SYNTHESIS OF STEROIDAL DIAZOLIDINONE, DIAZOLIDINTHIONE AND DIAZOLES: REACTION OF STEROIDAL DIBROMOKETONES WITH NUCLEOPHILIC NITROGEN

Journal of The Chilean Chemical Society

SHAMSUZZAMAN,¹  ABDUL BAQI, KHAN AAFTAB ALAM¹ 

[1] Aligarh Muslim University, India

关键词: Steroidal dibromoketone;    Diazolidinone;    Diazole;    Thiourea;    Urea;    Guanidine hydrochloride.;   

DOI  :  10.4067/S0717-97072014000300002

学科分类：化学（综合）

来源: Sociedad Chilena de Quimica

【 摘 要 】

Reaction of 5,6β-dibromo-5α-cholestan-3-one 1 with thiourea, urea and guanidine hydrochloride provided 3-hydroxycholest-3-eno [5α,6α-d] 1',3'-diazolidin-2'-thione 2, 3-hydroxycholest-3-eno [5α,6α-d] 1',3'-diazolidin-2'-one 3 and 3-hydroxycholest-3-eno [5α,6α-d] 2'-amino-1',3'-diazole 4 respectively. The structures of these products have been established on the basis of their elemental analysis and spectral data (IR, 1H NMR and MASS).

【 授权许可】

Unknown