Routine Cytogenetic Analysis of Chromosome Abnormalities in Acute Lymphoblastic Leukemia

International Journal of Biomedical Research

Chin Yuet Meng¹ 

[1] Cytogenetics Laboratory, Hematology Unit, Institute for Medical Research, Kuala Lumpur,

关键词: Acute lymphoblastic leukemia;    chromosome abnormalities;    prognosis;   

DOI  :  10.7439/ijbr.v6i9.2456

学科分类：基础医学

来源: Scholar Science Journals

【 摘 要 】

Acute lymphoblastic leukemia (ALL) is the most common cancer in children. Acquired chromosomal and genetic abnormalities have been used to define distinct biological and clinical subtypes of ALL. These aberrations have been shown to be associated with patient outcome and are used to direct therapy. Conventional cytogenetics analysis (CCA) is currently the gold standard to detect chromosome abnormalities in hematological malignancies. In this review we briefly describe the CCA methodology, advantages and limitations of CCA, the main chromosomal abnormalities and their prognostic significance in ALL.

【 授权许可】

CC BY