Antiphospholipid Syndrome - A silent killer

International Journal of Biomedical Research

Denita Fernandes¹  Kanika Gupta¹  Pushpanjali Singh²  Shravani Chalasani²  Vidyadhar B Bangal³ 

[1] Postgraduate Student (MS)Dept. of Obstetrics and GynecologyRural Medical College of Pravara Institute of Medical Sciences (Deemed University) Loni, Maharashtra;Postgraduate Student (MS)Dept. of Obstetrics and GynecologyRural Medical College of Pravara Institute of Medical Sciences (Deemed University) Loni, Maharashtra,;Professor and Head, Dept. of Obstetrics and Gynaecology,Rural Medical College, Loni, Maharashtra,

关键词: Antiphospholipid Syndrome;    Recurrent pregnancy loss;    Low molecular weight heparin;    Low dose aspirin;   

DOI  :  10.7439/ijbr.v5i11.793

学科分类：基础医学

来源: Scholar Science Journals

【 摘 要 】

Antiphospholipid Syndrome (APS) is a multisystem autoimmune disorder characterized by venous thrombosis, recurrent pregnancy loss, fetal death and presence of antiphospholipid antibodies (apla).The entity remains hidden unless suspected and investigated by the clinician. The target antigens of the antibodies are phospholipid binding proteins. By binding the phospholipids expressed by the trophoblasts, aPLA inhibit successful embryonic implantation into the endometrium. APS can be treated by combination of aspirin and heparin. The combination promotes successful embryonic implantation in the early stages of pregnancy and prevents thrombosis of the uteroplacental vasculature after placentation. Low molecular weight heparin has found to be more convenient , safe and effective in treatment of antiphospholipid antibody syndrome and inherited and acquired thrombophilias.

【 授权许可】

CC BY