SULFAMIC ACID CATALYZED FIVE COMPONENT REACTION FOR EFFICIENT AND ONE-POT SYNTHESIS OF DENSELY FUNCTIONALIZED TETRAHYDROPYRIDINE SCAFFOLD

Journal of The Chilean Chemical Society

SHINDE, DEVANAND B¹  SARKATE, ANIKETP¹  DHARBALE, NANASAHEB B¹  SARKATE, AJINKYA P²  SANGSHETTI, JAIPRAKASH N³ 

[1] Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, India;Poona College of Pharmacy, Pune, India;Y B Chavan College of Pharmacy, Aurangabad, India

关键词: Sulfamic acid;    functionalized tetrahydropyridines;    one-;    pot;    five component reaction.;   

DOI  :  10.4067/S0717-97072015000100012

学科分类：化学（综合）

来源: Sociedad Chilena de Quimica

【 摘 要 】

The utility of sulfamic acid in One-pot assembling of aromatic aldehydes, aromatic amines and β-keto esters to afford densely functionalized tetrahydropyridines in 70-89% yield has been presented. The advantage of sulfamic acid against other catalysts in terms of yield has been studied. The effect of different solvents on reaction time and yield has also been studied. Easy work up and mild reaction condition are the advantages of the proposed method.

【 授权许可】

Unknown