PLoS Pathogens | |
KIR2DL2 Enhances Protective and Detrimental HLA Class I-Mediated Immunity in Chronic Viral Infection | |
Mary Carrington1  Alison M. Vine2  Nafisa-Katrin Seich al Basatena2  Becca Asquith2  Charles R.M. Bangham2  Aidan MacNamara2  Chloe L. Thio3  Gregory D. Kirk3  Jacquie Astemborski3  Mitsuhiro Osame4  Koichiro Usuku5  James J. Goedert6  Salim I. Khakoo7  Sharyne M. Donfield8  | |
[1] Cancer and Inflammation Program, Laboratory of Experimental Immunology, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, United States of America;Imperial College, London, United Kingdom;Johns Hopkins University, Baltimore, Maryland, United States of America;Kagoshima University, Kagoshima, Japan;Kumamoto University, Kumamoto, Japan;National Cancer Institute, Rockville, Maryland, United States of America;Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, United States of America;Rho, Chapel Hill, North Carolina, United States of America | |
关键词: HTLV-1; Viral load; T cells; Major histocompatibility complex; Cytotoxic T cells; Hepatitis C virus; NK cells; Viral transmission; infection; | |
DOI : 10.1371/journal.ppat.1002270 | |
学科分类:生物科学(综合) | |
来源: Public Library of Science | |
【 摘 要 】
Killer cell immunoglobulin-like receptors (KIRs) influence both innate and adaptive immunity. But while the role of KIRs in NK-mediated innate immunity is well-documented, the impact of KIRs on theT cell responsein human disease is not known. Here we test the hypothesis that an individual's KIR genotype affects the efficiency of their HLA class I-mediated antiviral immune response and the outcome of viral infection. We show that, in two unrelated viral infections, hepatitis C virus and human T lymphotropic virus type 1, possession of the KIR2DL2 gene enhanced both protective and detrimental HLA class I-restricted anti-viral immunity. These results reveal a novel role for inhibitory KIRs. We conclude that inhibitory KIRs, in synergy with T cells, are a major determinant of the outcome of persistent viral infection.
【 授权许可】
CC BY
【 预 览 】
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RO201902016061619ZK.pdf | 788KB | download |