CIRCULATING CONCENTRATIONS OF IL-2, IL-6, TNF-ALPHA AND ENDOTOXIN IN PATIENTS OF CARCINOMA GALL BLADDER

International Journal of Biomedical Research

Lav Kumar Kacker¹  Induja Awasthi² 

[1] Ex- Professor, Department of Surgical Gastroenterology, CSMMU, Lucknow, U.P., India.;PhD Scholar,Department of Surgical Gastroenterology, CSMMU, Lucknow, U.P., India.

关键词: Obstructive jaundice;    Cholelithiasis;    Karnofsky score;   

DOI  :  10.7439/ijbr.v3i8.671

学科分类：基础医学

来源: Scholar Science Journals

【 摘 要 】

Introduction: Gallbladder Cancer represents the most common and aggressive type among the biliary tree cancers (BTCs). Carcinoma Gallbladder has an unusual geographic distribution. The highest incidence of carcinoma of gallbladder is in Chileans, American Indians, and in parts of North India. Objective: The present study was designed to characterise the circulating concentrations of endotoxin and different inflammatory mediators in patients with Carcinoma Gall bladder. Methods and Material: One hundred twenty eight Carcinoma Gall bladder patients were included in the study. Enzyme-linked immunosorbent assay was used for determining the circulating concentrations of Interleukin-2 (IL-2), Interleukin -6 (IL-6), Tumor Necrosis Factor-? (TNF-?)and Endotoxins in human serum. A cross sectional trial was performed. Results: The mean age of the patients was 50.8612.6 years. The mean duration of jaundice was since last 74.9150.0 days. Fifty five percent patients had cholelithiasis association with Carcinoma Gall bladder. The mean Body Mass Index (BMI) of Carcinoma Gall bladder patients were 18.332.8. The mean circulating concentrations of IL-2 were 33.3156.6 pg/ml, IL-6 were 167.16216.4 pg/ml, TNF-? were 56.0056.7 pg/ml and endotoxin were 0.660.2 EU/ml. Conclusions: Mean circulating concentrations of IL-2 and TNF-? were lower and mean circulating concentrations of IL-6 were higher than the previous studies. The mean circulating concentrations of endotoxin were within the normal limits. Which concludes that cytokines may participate in gallbladder carcinogenesis and the study provides evidence for a strong link between chronic inflammation and Carcinoma Gall bladder.

【 授权许可】

CC BY