Ebolavirus Evolution: Past and Present

PLoS Pathogens

Derek Stein¹  Marc-Antoine de La Vega²  Gary P Kobinger² 

[1] Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada;Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

关键词: Ebola virus;    Evolutionary rate;    Viral evolution;    Filoviruses;    Fruit bats;    Phylogenetic analysis;    Vaccines;    Viral vaccines;   

DOI  :  10.1371/journal.ppat.1005221

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

The past year has marked the most devastating Ebola outbreak the world has ever witnessed, with over 28,000 cases and over 11,000 deaths. Ebola virus (EBOV) has now been around for almost 50 years. In this review, we discuss past and present outbreaks of EBOV and how those variants evolved over time. We explore and discuss selective pressures that drive the evolution of different Ebola variants, and how they may modify the efficacy of therapeutic treatments and vaccines currently being developed. Finally, given the unprecedented size and spread of the outbreak, as well as the extended period of replication in human hosts, specific attention is given to the 2014–2015 West African outbreak variant (Makona).

【 授权许可】

CC BY