Persistence of Transmitted HIV-1 Drug Resistance Mutations Associated with Fitness Costs and Viral Genetic Backgrounds

PLoS Pathogens

Alexandra U. Scherrer¹  Mohaned Shilaih²  Sebastian Bonhoeffer³  Trevor Hinkley³  Jürg Böni³  Wan-Lin Yang³  the Swiss HIV Cohort Study (SHCS)⁴  Huldrych F. Günthard⁵  Roger D. Kouyos⁵  Sabine Yerly⁵  Thomas Klimkait⁵  Christos Petropoulos⁵  Vincent Aubert⁶ 

[1] Department Biomedicine—Petersplatz, University of Basel, Basel, Switzerland;Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland;Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland;Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland;Institute of Medical Virology, University of Zurich, Zurich, Switzerland;Laboratory of Virology and AIDS Center, Geneva University Hospital, Geneva, Switzerland

关键词: Antimicrobial resistance;    Microbial mutation;    Genetic epidemiology;    HIV epidemiology;    Fitness epistasis;    Mutation detection;    Viral persistence;    latency;    HIV-1;   

DOI  :  10.1371/journal.ppat.1004722

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Transmission of drug-resistant pathogens presents an almost-universal challenge for fighting infectious diseases. Transmitted drug resistance mutations (TDRM) can persist in the absence of drugs for considerable time. It is generally believed that differential TDRM-persistence is caused, at least partially, by variations in TDRM-fitness-costs. However, in vivo epidemiological evidence for the impact of fitness costs on TDRM-persistence is rare.

【 授权许可】

CC BY