SYNTHESIS, CRYSTAL STRUCTURE AND ANTIOXIDANT POTENTIAL OF DI-(TV-CINNAMYL) FLUOXETINE CHLORIDE

Journal of The Chilean Chemical Society

ULLAHKHAN, ISLAM¹  HUSAAIN, ERUM A²  KANWAL, NOSHEEN²  BUYUKGUNGOR, ORHAN³  SAHIN, ONUR³ 

[1] GC University, Lahore, Pakistan;Lahore College for Women University, Lahore, Pakistan;Ondokuz Mayis University, Samsun, Turkey

关键词: Fluoxetine;    Derivative;    Crystal structure;    Antioxidant activity;   

DOI  :  10.4067/S0717-97072013000100001

学科分类：化学（综合）

来源: Sociedad Chilena de Quimica

【 摘 要 】

A new derivative of Fluoxetine, N,N-dicinnamyl-N-methyl-3-phenyl-3- [4-(trifluoromethyl) phenoxy]butan-1-aminium chloride hydrate [Di-(N-Cinnamyl) Fluoxetine Chloride hydrate] was synthesized and characterized by single-crystal X-ray diffraction studies, elemental analyzer, thermogravimetric and FTIR spectroscopy analysis. The titled compound [C35H37ClF3NO2] crystallized in monoclinic, having unit cell parameters a = 19.155(14) A°, b = 9.193(5) A°, c = 18.596(13) A° and belongs to P21/c space group. The molecule shows disorder of F atoms and was modeled as two different orientations. The one-dimensional crystal packing features weak C-H … π interactions showing the formation of a chain along [001], provides stability to the crystal lattice. Antioxidant potential of Di-(N-Cinnamyl) Fluoxetine Chloride hydrate has been described and was found higher than Fluoxetine and N-Benzyl Fluoxetine.

【 授权许可】

Unknown