CENTRAL NERVOUS SYSTEM DEPRESSANT ACTIVITY OF AQUEOUS EXTRACT OF CISSUS QUADRANGULARIS

International Journal of Biomedical Research

S. J. Mundada¹  H. R. Ade²  D. R. Dewade³  A. M. Agrawal⁴ 

[1] Department of Pharmacognosy, Bharati Vidyapeeth College of Pharmacy, CBD Belapur, Navi Mumbai, Maharashtra;Department of Pharmacology, S.G.S.P.S. Institute of Pharmacy, Kaulkhed, Dist: Akola, Maharashtra;Department of Pharmacology, S.G.S.P.S. Institute of Pharmacy, Kaulkhed, Dist: Akola, Maharashtra.;Department of Pharmacovigilance, Tata Consultancy Services (Astrazeneca), Mumbai, Maharashtra

关键词: Antianxiety;    Antiaggressive;    Cissus quadrangularis;    Muscle coordination;   

DOI  :  10.7439/ijbr.v1i3.67

学科分类：基础医学

来源: Scholar Science Journals

【 摘 要 】

The research work deals with the screening of aqueous extracts of Cissus quadrangularis (CQ) stem for central nervous system (CNS) depressant activity. The CQ leaves and stems contain resveratrol, piceatannol, pallidol perthenocissin derivatives as chemical components and are reported to have anticonvulant activity. The extract of plant showed GABAA- benzodiazepine receptor binding activity we made an attempt to study its CNS depressant effect. The different activities studied were test for locomotor activity, effect on muscle co-ordination, antiaggressive and antianxiety activities. The result of the study reflected that aqueous extract of the stem (150 mg/kg, p.o) decreased locomotor activity, produced muscle relaxation and showed antianxiety and antiaggressive activity

【 授权许可】

CC BY