KINETICS AND MECHANISTIC STUDY OF OXIDATION OF AMOXICILLIN BY CHLORAMINE-T IN ACID MEDIUM

Journal of The Chilean Chemical Society

MURALIDHARA, H. B¹  YOGESH KUMAR, K¹  VEENA, M. S²  ARTHOBA NAYAKA, Y³  PRASHANTH, M. K⁴ 

[1] Jain University, Bangalore, India;K.S. Institute of Technology, Bangalore, India;Kuvempu University, Shankaraghatta;P.N.S. Institute of Technology, Bangalore, India

关键词: Amoxicillin;    Chloramines-;    T;    Kinetics;    Mechanistic;    Oxidation.;   

DOI  :  10.4067/S0717-97072015000300019

学科分类：化学（综合）

来源: Sociedad Chilena de Quimica

【 摘 要 】

This spectroscopic study presents the kinetics and degradation pathways of oxidation of amoxicillin (AMOX) by chloramines-T (CAT) in acidic medium at a constant ionic strength of 0.105 mol dm-3 at 298 K. Reaction between AMOX and CAT in acidic medium exhibits 1:1 stoichiometry (AMOX:CAT). The reaction is of a first-order in both [CAT] and [AMOX]. The order with respect to acid concentration was fractional. The effects of added products, ionic strength and dielectric constant have been studied. The main oxidation product of AMOX was identified by IR, 1H NMR and mass spectra. The reaction constants involved in the different steps of the mechanisms were calculated. Activation parameters with respect to slow step of the mechanisms were computed and discussed.

【 授权许可】

Unknown