Layered double hydroxides: inorganic nanoparticles for storage and release of species of biological and therapeutic interest

Quimica nova

Tronto, Jairo¹  Valim, João B.²  Cunha, Vanessa R. R.³  Ferreira, Ana Maria da C.³  Constantino, Vera R. L.³ 

[1] Universidade Federal de Viçosa, Rio Paranaíba, Brasil;Universidade de São Paulo, Ribeirão Preto;Universidade de São Paulo, São Paulo, Brasil

关键词: layered double hydroxides;    inorganic carriers;    drug release.;   

DOI  :  10.1590/S0100-40422010000100029

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Studies aboutthe inorganic nanoparticles applying for non-viral release of biological andtherapeutic species have been intensified nowadays. This work reviews the preparationstrategies and application of layered double hydroxides (LDH) as carriers forstoring, carrying and control delivery of intercalated species as drugs andDNA for gene therapy. LDH show low toxicity, biocompatibility, high anion exchangecapacity, surface sites for functionalization, and a suitable equilibrium betweenchemical stability and biodegradability. LDH can increase the intercalated speciesstability and promote its sub-cellular uptake for biomedical purposes. Concerningthe healthy field, LDH have been evaluated for clinical diagnosis as a biosensorcomponent.

【 授权许可】

CC BY