Glycated hemoglobin: A surrogate marker of coronary artery diseases?

International Journal of Biomedical Research

Shani Constin¹ 

[1] Resident, Department of General Medicine, Father Muller Medical College, Mangalore - 575002

关键词: Glycated hemoglobin;    lipid profile;    dyslipidemia;    coronary artery disease;   

DOI  :  10.7439/ijbr.v8i4.4043

学科分类：基础医学

来源: Scholar Science Journals

【 摘 要 】

Background: Diabetes mellitus is a global epidemic defined by an elevated glycated hemoglobin (HbA1c). The symbiotic relationship between diabetes and dyslipidemia has been studied and glycated hemoglobin has been projected as a potential marker for coronary artery diseases.Aim: To study the correlation between the HbA1c and the lipid ratios / individual lipidsMethods: The data was collected from 90 patients of type 2 Diabetes Mellitus over a period of 6 months, after an informed written consent. The study subjects were divided according to the HbA1c values into three groups - Group A: HbA1c < 7%, Group B: HbA1c /= 7%, Group C: HbA1c >10 %. The lipid profiles of the patients after a minimum of 8 hours of fasting were noted. The values of the lipid ratios and the individual lipids were mapped against the HbA1c values of each group. The correlation between the glycated hemoglobin and the lipid profile was analysed.Results: The maximum number of patients (30%) were in the 6th decade of life. Among the study subjects, 39 patients (43.33%) were females and 51 patients (56.66%) were males. Group B had the majority of patients (44.4%) followed by group A. There was a positive correlation between HbA1c and triglycerides (p=0.04) and a negative correlation between HbA1c and HDL (p=0.003). There was a positive correlation between HbA1c and LDL/HDL (p=0.022), TG/HDL (p=0.008) and TC/HDL (p=0.007). Thus the TC/HDL ratio was most impaired by a rise in HbA1c when compared with other lipid ratios.Conclusion: There is a significant positive correlation between HbA1c and lipid ratios. Lipid ratios in turn are important predictors of CAD. Hence HbA1c can be used to predict dyslipidemia and CAD in patients with Type 2 diabetes mellitus and can be used as a surrogate marker for the same.

【 授权许可】

CC BY