Viral OTU Deubiquitinases: A Structural and Functional Comparison

PLoS Pathogens

Brian L. Mark¹  Ben A. Bailey-Elkin¹  Puck B. van Kasteren²  Eric J. Snijder²  Marjolein Kikkert² 

[1] Department of Microbiology, University of Manitoba, Winnipeg, Canada;Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands

关键词: Proteases;    Eukaryota;    Yeast;    RNA viruses;    Viral replication;    Viral structure;    Arteriviruses;    Crystal structure;   

DOI  :  10.1371/journal.ppat.1003894

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Recent studies have revealed that proteases encoded by three very diverse RNA virus groups share structural similarity with enzymes of the Ovarian Tumor (OTU) superfamily of deubiquitinases (DUBs). The publication of the latest of these reports in quick succession prevented proper recognition and discussion of the shared features of these viral enzymes. Here we provide a brief structural and functional comparison of these virus-encoded OTU DUBs. Interestingly, although their shared structural features and substrate specificity tentatively place them within the same protease superfamily, they also show interesting differences that trigger speculation as to their origins.

【 授权许可】

CC BY