Kinetics of rabies antibodies as a strategy for canine active immunization

Journal of venomous animals and toxins

tima Alves Martorelli¹  Falcã²  o da Costa³  Selene Daniela Babboni⁵  Rafael Modolo⁶  Cassiano Victoria⁶  Ana Paula de Arruda Geraldes Kataoka⁷  Carlos Roberto Padovani⁸  Luzia de Fá⁹  Hení⁹  José^1,10 

[1] Univ Estadual Paulista), AraçUniv Estadual Paulista), Botucatu, Brazil;Department of Animal Health and Production, Veterinary Medicine School, SãDepartment of Biostatistics, Botucatu Biosciences Institute, SãDepartment of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Husbandry, SãLaboratory of Zoonoses and Vector-Borne Diseases, Center for the Control of Zoonosis of Sãatuba, Brazil;o Paulo City, São Paulo State University (UNESP –o Paulo, Brazil

关键词: Rabies;    Dogs;    Vaccination;    Revaccination;    Annual vaccination campaign;    Fuenzalida-Palácios;   

DOI  :  10.1186/1678-9199-20-37

学科分类：药理学

来源: BioMed Central

【 摘 要 】

Rabies, a zoonosis found throughout the globe, is caused by a virus of the Lyssavirus genus. The disease is transmitted to humans through the inoculation of the virus present in the saliva of infected mammals. Since its prognosis is usually fatal for humans, nationwide public campaigns to vaccinate dogs and cats against rabies aim to break the epidemiological link between the virus and its reservoirs in Brazil. During 12 months we evaluated the active immunity of dogs first vaccinated (booster shot at 30 days after first vaccination) against rabies using the Fuenzalida-Palácios modified vaccine in the urban area of Botucatu city, São Pauto state, Brazil. Of the analyzed dogs, 54.7% maintained protective titers (≥0.5 IU/mL) for 360 days after the first vaccination whereas 51.5% during all the study period. The present results suggest a new vaccination schedule for dogs that have never been vaccinated. In addition to the first dose of vaccine, two others are recommended: the second at 30 days after the first and the third dose at 180 days after the first for the maintenance of protective titers during 12 months.

【 授权许可】

CC BY