DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status

Journal of venomous animals and toxins

Suzana Madeira Dió¹  mara Marques Pereira¹  Fá¹  Adriana Sierra Assencio Almeida Barbosa²  tima Regina Vilani-Moreno³  rio³  Carlos Roberto Gonç³  Larissa Ragozo Cardoso Oliveira⁴  Francilene Capel Tavares⁶  Sueli Aparecida Calvi⁷  Paulo Câ⁷  alves Lima⁷ 

[1] Univ Estadual Paulista), Botucatu, Brazil;Biology Technical Team, Lauro de Souza Lima Institute, Bauru, Brazil;Department of Tropical Diseases and Image Diagnosis, Botucatu Medical School, SãEquipe TéMicrobiology Technical Team, Lauro de Souza Lima Institute, Bauru, Brazil;cnica de Biologia, Instituto Lauro de Souza Lima, Bauru, Brazil;o Paulo State University (UNESP –

关键词: Jorge Lobo’ disease;    Lacazia loboi;    Malnutrition;    Mice;    Genotoxicity;    Comet assay;   

DOI  :  10.1186/s40409-015-0006-y

学科分类：药理学

来源: BioMed Central

【 摘 要 】

Jorge Lobo’s disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus Lacazia loboi. Herein we report a study that relates the genotoxicity caused by L. loboi in isogenic mice with nutritional status, through a normal or restricted diet. DNA damage was assessed in the peripheral blood by the comet assay (tail intensity). The results for leukocytes showed increases in the mean tail intensity in mice under dietary restriction, in infected mice under dietary restriction and in infected mice ingesting a normal diet. These results indicate that dietary restriction and L. loboi infection may increase DNA damage levels in mice, as detected by the comet assay.

【 授权许可】

CC BY