Study of oxidative stress in relation with antioxidant status in chronic bronchitis

International Journal of Biomedical Research

Dr. Anita Madhav Raut¹ 

[1] Dr. Vikhe Patil Institute of Medical Sciences.Ahmednagar (MS)

关键词: Key words- Malondialdehyde;    Alpha-tocopherol;    Total Antioxidant Capacity;    Chronic bronchitis;   

DOI  :  10.7439/ijbr.v3i7.600

学科分类：基础医学

来源: Scholar Science Journals

【 摘 要 】

Oxidative stress has been recognized as a central feature of smoke induced chronic bronchitis. Where lipid peroxide play an important role in inflammatory lung disease. Increased lipid peroxide increases epithelial permeability produced by cigarette smoke is likely to be mediated though depletion of the Total Antioxidant Capacity. Imbalance between oxidants and Total Anioxidant Capacity is also an established fact in these patients. 60 patients with chronic bronchitis included in the study. Their base line clinical examination, malondialdehyde (MDA), nitric oxide, alpha tochopherol and Total Antioxidant Capacity were measured. 100 healthy non-smokers’ were served as controls. The mean malondialdehyde levels and nitric oxide in the patients at base line were higher than Controls (p<0.001). Plasma alpha-tocopherol and total antioxidant capacity were lower (p<0.001) in the patients compared to controls. The present study shows that initially the plasma lipid peroxide (MDA) levels were high and antioxidants. (alpha- tocopherol, total antioxidant capacity) were low in patients with chronic bronchitis. Our results suggest the presence of oxidative stress and decrease in total antioxidant capacity in chronic bronchitis.

【 授权许可】

CC BY