Improving the solubility of the antichagasic drug benznidazole through formation of inclusion complexes with cyclodextrins

Quimica nova

Alves, Lariza Darlene Santos¹  Rolim Neto, Pedro José¹  Soares, Mônica Felts de La Roca²  Sobrinho, José Lamartine Soares²  Labandeira, Juan Jose Torres³ 

[1] Universidade Federal de Pernambuco, Recife, Brasil;Universidade Federal do Piauí, Teresina, Brasil;Universidade de Santiago de Compostela, Santiago de Compostela, Espanha

关键词: benznidazole;    Chagas disease;    inclusion complex and dissolution.;   

DOI  :  10.1590/S0100-40422011000900010

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

This study describes unpublished research on improving the solubility of benznidazole by the formation of an inclusion complex. The cyclodextrins selected were αCD, βCD, γCD, HPβCD, RMβCD and SBβCD. All complexes were obtained in solution, presenting 1:1 stoichiometry according to the phase solubility diagram. The highest association constants were obtained with RMβCD and SBβCD, being selected for attainment of solid state complexes. These were characterized using XRD, SEM and dissolution test. The data obtained suggest the formation of complexes and indicate that these may provide a promising alternative way of developing solid doses of drug with suitable biopharmaceutical properties.

【 授权许可】

CC BY