STUDIES ON THE ALKYLATION OF QUINOLIN-2(1H)-ONE DERIVATIVES

Journal of The Chilean Chemical Society

CHEN, CHIA-LING¹  TZENG, CHERNG-CHYI²  CHANG, KEN-MING²  CHEN, JIH-JUNG³  WANG, TAI-CHI³  CHEN, I-LI³  HSIEH, HAN-JIE³  WEI, DAU-CHANG³ 

[1] KUO General Hospital, Tainan City, Taiwan;Kaohsiung Medical University, Kaohsiung, Taiwan;Tajen University, Pingtung, Taiwan

关键词: N-;    Alkylation;    O-;    Alkylation;    Quinolin-;    2(1H)-;    one.;   

DOI  :  10.4067/S0717-97072015000100008

学科分类：化学（综合）

来源: Sociedad Chilena de Quimica

【 摘 要 】

Alkylation of quinolin-2(1H)-one (1) and its C(6) and C(7) substituted dervatives (OMe, OBn, and Cl) with 2-bromoacetophenone or chloroacetone under basic condition (K2CO3 in DMF) gave a mixture of N1- and O2- alkylated products with the former one as a major product. However, alkylation of 8-methoxy-, 8-benzyloxy-, and 8-chloro- quinolin-2(1H)-ones under the same reaction conditions gave exclusively O2-alkylated products.

【 授权许可】

Unknown