Influenza A Virus Migration and Persistence in North American Wild Birds

PLoS Pathogens

Garnet Raven¹  Scott Krauss²  David Walker³  Mathieu Fourment⁴  Gavin J. D. Smith⁵  Ian H. Mendenhall⁵  Denise Kühnert⁵  Yvonne C. F. Su⁵  Richard J. Webby⁶  Lawrence J. Niles⁷  Angela Danner⁷  Alexei J. Drummond⁸  David E. Wentworth⁸  Timothy B. Stockwell⁸  Robert G. Webster⁸  S. Paul Pryor⁹  Justin Bahl⁹  Rebecca A. Halpin⁹  Vivien G. Dugan⁹ 

[1] Allan Wilson Centre for Molecular Ecology and Evolution, University of Auckland, Auckland, New Zealand;Center for Infectious Diseases, The University of Texas School of Public Health, Houston, Texas, United States of America;Conserve Wildlife Foundation of New Jersey, Bordentown, New Jersey, United States of America;Department of Computer Science, University of Auckland, Auckland, New Zealand;Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America;Division of Microbiology and Infectious Diseases/National Institute of Allergy and Infectious Diseases/National Institutes of Health/Department of Health and Human Services, Bethesda, Maryland, United States of America;Environment Canada, Canadian Wildlife Service, Edmonton, Alberta, Canada;J. Craig Venter Institute, Rockville, Maryland, United States of America;Laboratory of Virus Evolution, Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, Singapore

关键词: Phylogenetic analysis;    Animal migration;    Influenza A virus;    Bird genetics;    Alberta;    Avian influenza;    Delaware;    Bird genomics;   

DOI  :  10.1371/journal.ppat.1003570

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Wild birds have been implicated in the emergence of human and livestock influenza. The successful prediction of viral spread and disease emergence, as well as formulation of preparedness plans have been hampered by a critical lack of knowledge of viral movements between different host populations. The patterns of viral spread and subsequent risk posed by wild bird viruses therefore remain unpredictable. Here we analyze genomic data, including 287 newly sequenced avian influenza A virus (AIV) samples isolated over a 34-year period of continuous systematic surveillance of North American migratory birds. We use a Bayesian statistical framework to test hypotheses of viral migration, population structure and patterns of genetic reassortment. Our results reveal that despite the high prevalence of Charadriiformes infected in Delaware Bay this host population does not appear to significantly contribute to the North American AIV diversity sampled in Anseriformes. In contrast, influenza viruses sampled from Anseriformes in Alberta are representative of the AIV diversity circulating in North American Anseriformes. While AIV may be restricted to specific migratory flyways over short time frames, our large-scale analysis showed that the long-term persistence of AIV was independent of bird flyways with migration between populations throughout North America. Analysis of long-term surveillance data provides vital insights to develop appropriately informed predictive models critical for pandemic preparedness and livestock protection.

【 授权许可】

CC BY