Dopaminergic agents and erectile dysfunction treatment

Quimica nova

Neves, Gilda¹  Rates, Stela M. K.¹  Fraga, Carlos A. M.¹  Barreiro, Eliezer J.¹ 

[1] Universidade Federal do Rio Grande do Sul, Porto Alegre

关键词: erectile dysfunction;    dopaminergic agents;    apomorphine.;   

DOI  :  10.1590/S0100-40422004000600020

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The understandingof the scientific basis of the erectile function expanded rapidly the rangeof therapies for treating erectile dysfunction in recent years. This articlereviews the role of dopamine on the erection mechanisms and its importance fornew pro-erectile drug design. The ability of dopaminergic agents to elicit penileerection has been described since 1975 and successively confirmed by numerousstudies. The development of apomorphine SL (dopaminergic non selective agonist)to enhance erectile function represents a new pharmacological approach to themanagement of erectile dysfunction using CNS drugs. The search for selectiveD4 dopaminergic agents is being explored by some research groupsand pharmaceutical companies.

【 授权许可】

CC BY