Acid and alkali burns of the esophagus: An experimental study

Scientific Research and Essays

Ozgur Katrancioglu¹ 

关键词:  ;    Alkali;    acid;    corrosive esophageal burns;    rat.;   

DOI  :  10.5897/SRE10.628

学科分类：社会科学、人文和艺术（综合）

来源: Academic Journals

【 摘 要 】

The purpose of the study was to evaluate esophageal burn in a rat model using varying concentrations of acid and alkali substances commonly used in daily life. Wistar Albino rats were used in this experimental model (n = 35). One control group and four working groups were designated with 7 animals in each. The control group was given serum physiologic into the esophagus; Groups I and II were administered sodium (Na) hypochloride (acid) in concentrations of 2.5 and 5%, respectively; and Groups III and IV were administered Na hydroxide (alkali) in concentrations of 2.5 and 5%, respectively. After 24 h, samples were taken from the esophagus and the damage was evaluated in submucosa, muscularis mucosa and tunica muscularis, and the total burn scores were determined. Total burn score in the control group was 0.28±0.48; in Group I 2.28±0.95, in Group II 2.43±0.78, in Group III 3.00±0.57 and in Group IV 3.57±0.53. Significant differences were determined in total burn score between all study groups compared with the control group. There were significant differences between Groups I and IV and between Groups II and IV regarding muscularis damage (p<0.05). When the data were evaluated, there was more definite esophageal burn in both acid and alkali groups than in the control group. When the acid and alkali groups (of same concentrations) were compared, damage in the alkali group was greater. Also, the paper concluded that the type of substance given to esophagus as well as its concentration is important in esophageal burns.

【 授权许可】

CC BY