SYNTHESIS AND STUDY ON MAGNETIC RESONANCE IMAGING PERFORMANCE OF GD(III)-DTPA-BISBENZOTHIAZOL HYDRAZIDE

Journal of The Chilean Chemical Society

LI, CHANG-CHENG¹  ZHANG, TIAN-KAI¹  JIANG, LIN¹  WAN, FU-XIAN¹  LI, YING¹ 

[1]Shan Dong Agricultural University, Taian, Republic of China

关键词: MRI contrast agent;    benzothiazole;    DTPA derivative;    gadolinium complex;    relaxivity;   

DOI  :  10.4067/S0717-97072016000200003

学科分类：化学（综合）

来源: Sociedad Chilena de Quimica

【 摘 要 】

In this paper, 2-hydrazino-6-methoxy-1,3-benzothiazole was introduced into diethylenetriamine pentaacetic (DTPA) by acylation reaction. The corresponding non-ion Gd(III) complex holding promise of a single molecule magnetic resonance imaging (MRI) contrast agent was obtained by treating this ligand with GdCl3·6H2 O. The efficacy of the contrast agent was assessed by measuring the longitudinal relaxivity (r1), the r1 of Gd(III)-DTPA-bisbenzothiazole hydrazide was up to 6.44 mM-1,s-1, which was 1.8 times higher than that of the analogous MRI contrast agent Gd(III)-DTPA (r1 = 3.64 mM-1s-1) in commercial use. In addition, in vitro MR images on a 0.5 T magnetic field exhibited a remarkable enhancement of signal contrast for Gd(III)-DTPA-bisbenzothiazole hydrazide than Gd(III)-DTPA. These results demonstrate that this non-ion Gd(III) complex acts as a potentially MRI contrast agent.

【 授权许可】

Unknown