Activation of mice peritoneal macrophages by palladium(II) organometallic mononuclear compounds

Quimica nova

Carlos, Iracilda Zeppone¹  Santana, Anderson Martinez¹  Godoy Netto, Adelino Vieira de¹  de Almeida, Eduardo Tonon¹  Mauro, Antonio Eduardo¹ 

[1] Universidade Estadual Paulista, Araraquara

关键词: palladium(II) complexes;    macrophages;    hydrogen peroxide.;   

DOI  :  10.1590/S0100-40422005000300008

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The immune responsesare mediated by a variety of cells that, when activated, produce a number ofmolecules. Macrophages are the first cells to take part in the immune responsereleasing many compounds in the extracellular environment such as H2O2.Taking into account this aspect we evaluated the activation of an immunologicalsystem, in vitro, by determining the H2O2 releasedin cultures of peritoneal macrophage cells from Swiss mice in the presence oforganopalladated compounds of the type [Pd(dmba)(X)(dppp)], dmba = N,N-dimethylbenzylamine,dppp = 1,3-bis(diphenylphosphine)propane, X = Cl, N3, NCO, NCS. Anexcellent activation of macrophages by the [Pd(dmba)(X)(dppp)] compounds wasobserved and the influence of the X ligand on the immune response could be verified.

【 授权许可】

CC BY