The Recessive model of 677C>T Polymorphism in MTHFR gene increase moderately the risk of Colorectal Cancer in Moroccan patients

International Journal of Biomedical Research

Youssef Bakri¹  Amzazi¹  Rachid Aboukhalid¹  Falak Azzam¹  Abdelilah Laraqui²  Idriss Lahlou-amine²  Hicham El Rhaffouli²  Fatima El Boukhrissi³ 

[1] Biochemistry and immunology laboratory, Mohammed V University, Faculty of Sciences Rabat;Mohammed V Military Hospital, Biosecurity P3 Laboratory;Moulay Ismail Military Hospital, Biochemistry Laboratory

关键词: MTHFR;    C677T;    polymorphism;    colorectal cancer;    Moroccan patients;   

DOI  :  10.7439/ijbr.v6i6.2054

学科分类：基础医学

来源: Scholar Science Journals

【 摘 要 】

Methylenetetrahydrofolate reductase (MTHFR) is a critical folate-metabolising enzyme and a polymorphism at position 677 (C677T), is associated with reduced enzyme activity. We investigated whether this functional polymorphism modulates the risk of developing Colorectal Cancer (CRC).We conducted a hospital-based case-control study to assess the association of MTHFR gene polymorphism C677T with risk for colorectal cancer in a Moroccan population. Odds ratios (ORs)with corresponding 95% confidence intervals (Cis) were used to assess the association.The analysis had shown the significant elevated risk of cancer was associated with the MTHFRC677T polymorphism in recessive model (OR=2.81, 95% CI; (1.13-7.06),P=0.027) compared the other genetic models. Simultaneously, the T-allele genotype versus C-allele genotype was not associated with CRC risk (ORa = 1.355; 95% CI = 0.94-1.96 and p = 0.10).Thus recessive model are significantly associated in the risk of colorectal cancer. Further larger-scale studies are necessary to confirm our finding.

【 授权许可】

CC BY