SOLVENT FREE OXALIC ACID CATALYZED SYNTHESIS OF 1,5-BENZODIAZEPINES

Journal of The Chilean Chemical Society

WAKTE, PRAVIN S¹  SHINDE, DEVANAND B¹  SARKATE, ANIKET P¹  DHARBALE, NANASAHEB B²  SARKATE, AJINKYA P³  SANGSHETTI, JAIPRAKASH N⁴ 

[1] Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, India;Shri Bhagwan College of Pharmacy, Aurangabad, India;Sinhgad Institute of Pharmacy, Pune, India;Y. B. Chavan College of Pharmacy, Aurangabad, India

关键词: 1;    5-;    benzodiazepine;    oxalic acid;    solvent free conditions;    α    β    -;    unsaturated ketones;    o-;    phenylenediamine.;   

DOI  :  10.4067/S0717-97072013000400064

学科分类：化学（综合）

来源: Sociedad Chilena de Quimica

【 摘 要 】

In the present study 1, 5-benzodiazepines were synthesized from a range of α, β-unsaturated ketones and o-phenylendiamine using oxalic acid 10 mol% as a catalyst under solvent free conditions. The yields of the present method are better than the reported method which explains effectiveness of oxalic acid catalyst. The cost effective, resourceful, undemanding and environment friendly are the advantageous aspects of this method.

【 授权许可】

Unknown