Tropical biodiversity: has it been a potential source of secondary metabolites useful for medicinal chemistry?

Quimica nova

Lopes, Márcia Nasser¹  Silva, Dulce Helena Siqueira¹  Araújo, Ângela Regina¹  Bolzani, Vanderlan da Silva¹  Pivatto, Marcos¹  Danuello, Amanda¹  Furlan, Maysa¹  Castro-Gamboa, Ian¹  Valli, Marilia¹  Cavalheiro, Alberto José¹ 

[1] Universidade Estadual Paulista Júlio de Mesquita Filho, Araraquara, Brasil

关键词: natural products;    medicinal chemistry;    tropical biodiversity.;   

DOI  :  10.1590/S0100-40422012001100036

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The use of natural products has definitely been the most successful strategy in the discovery of novel medicines. Secondary metabolites from terrestrial and marine organisms have found considerable use in the treatment of numerous diseases and have been considered lead molecules both in their natural form and as templates for medicinal chemistry. This paper seeks to show the great value of secondary metabolites and emphasize the rich chemical diversity of Brazilian biodiversity. This natural chemical library remains understudied, but can be a useful source of new secondary metabolites with potential application as templates for drug discovery.

【 授权许可】

CC BY