Emerging Functions for the Staphylococcus aureus RNome

PLoS Pathogens

Marc Hallier¹  Brice Felden¹  Julien Guillet¹ 

[1] Rennes University, Inserm U835-UpresEA2311, Pharmaceutical Biochemistry, Rennes, France

关键词: Staphylococcus aureus;    Messenger RNA;    Ribonucleases;    Gene expression;    Virulence factors;    Antisense RNA;    Protein translation;    Gene regulation;   

DOI  :  10.1371/journal.ppat.1003767

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Staphylococcus aureus is a leading pathogen for animals and humans, not only being one of the most frequently isolated bacteria in hospital-associated infections but also causing diseases in the community. To coordinate the expression of its numerous virulence genes for growth and survival, S. aureus uses various signalling pathways that include two-component regulatory systems, transcription factors, and also around 250 regulatory RNAs. Biological roles have only been determined for a handful of these sRNAs, including cis, trans, and cis-trans acting RNAs, some internally encoding small, functional peptides and others possessing dual or multiple functions. Here we put forward an inventory of these fascinating sRNAs; the proteins involved in their activities; and those involved in stress response, metabolisms, and virulence.

【 授权许可】

CC BY