Specificity and selectivity improvement in doping analysis using comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry

Quimica nova

Silva Júnior, Ademário I. da¹  Silva, Raphael S. F.²  Barbosa, Samantha S.²  Aquino Neto, Francisco R.²  Pereira, Henrique Marcelo G.²  Leal, Felipe D.²  Padilha, Monica C.² 

[1] Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro, Rio de Janeiro, Brasil;Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil

关键词: comprehensive two-dimensional gas chromatography;    doping analysis;    time-of-flight.;   

DOI  :  10.1590/S0100-40422012000500022

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry was used for the identification of forty doping agents. The improvement in the specificity was remarkable, allowing the resolution of analytes that could not be done by one-dimensional chromatographic systems. The sensitivity observed for different classes of prohibited substances was clearly below the value required by the World Anti-Doping Agency. In addition time-of-flight mass spectrometry gives full spectrum for all analytes without any interference from the matrix, resulting in selectivity improvements. These results could support the implementation of an exhaustive monitoring approach for hundreds of doping agents in a single injection.

【 授权许可】

CC BY