ROLE OF GLUTAMINE SUPPLEMENTATION ON IMPROVING THE NUTRITIONAL, FUNCTIONAL AND IMMUNOLOGICAL STATUS OF MALIGNANT OBSTRUCTIVE JAUNDICE PATIENTS AT A TERTIARY CARE CENTRE.

International Journal of Biomedical Research

Anup Kumar Wahal¹  S M Natu¹  Abhijit Chandra¹  Pankaj Kumar¹  Lav Kumar Kacker¹  Induja Awasthi¹ 

[1] Department of Surgical Gastroenterology, CSMMU.

关键词: Glutamine;    Malignant;    Obstructive Jaundice;   

DOI  :  10.7439/ijbr.v2i3.95

学科分类：基础医学

来源: Scholar Science Journals

【 摘 要 】

Introduction:Incidence of carcinoma gall bladder in India ranges from 1.01/100000 for males to 10.1/100000 for females.Glutamine decreases intestinal permeability, maintain intestinal barrier and attenuate systemic inflammatory response. Objectives:Assessment of Nutritional status, functional status and mortality in Glutamine supplemented (Gp.A) /Non- supplemented (Gp.B) Malignant Obstructive Jaundice (MOJ) patients in which endoscopic drainage /surgery was impossible. Methods:Fifty patients Gp.A-25 and Gp.B-25,were included in the study.Supplementation was 50 ml (20g)/day intravenously to the patients for 3 days and 30g/day orally for 4 days. BMI,Karnofsky Score and mortality were assessed on 42nd day. Results:Gp. A mean BMI was 16.32+2.64 on admission and 16.37+3.42 on 42nd day. In Gp.B mean BMI on admission was 18.15+1.27 which improved to 21.35+2.53on 42nd day.In Gp.A mean Karnofsky score was 55.60+20.02 on admission and 21.20+25.71 on 42nd day.In Gp.B mean Karnofsky score on admission was 60.00+19.58 and 24.00+33.54 on 42nd day.The mean IL-2 Level in Gp.A was 13.93+26.80 pg/ml on admission and 81.30+79.46 pg/ml on 42nd day.The mean IL-2 Level in Gp.B was 9.07+26.93 pg/ml on admission which reduced to 8.27+15.21 pg/ml on 42nd day.IL-6 Level in Gp.A was 79.43+96.83pg/ml on admission and173.10+217.94pg/ml on 42nd day.IL-6 Level in Gp.B was 390.06+345.22 pg/ml on admission which reduced to 230.71+201.65pg/ml on 42nd day.TNF-α Level in Gp.A was 59.53+56.63pg/ml on admission  and 202.30+224.84pg/ml on 42nd day. TNF-α Level in Gp.B was 95.33+ 72.21 pg/ml on admission which reduced to 67.80+52.35pg/ml on 42nd day. Conclusion:Glutamine supplementation helps in improving the Nutritional status and reducing mortality of MOJ patients.

【 授权许可】

CC BY