Effect of Grand Multiparity on Certain Thyroid Function Tests

International Journal of Biomedical Research

Kamal Eldin Ahmed Abdelsalam¹ 

[1] Professor of Chemical Pathology, College of Applied Medical Sciences, Shaqra University. KSA.

关键词: thyroxine;    triiodothyronine;    thyrotropin;    Thyroxine Binding Globulin;    gr;    multiparas;   

DOI  :  10.7439/ijbr.v6i1.1525

学科分类：基础医学

来源: Scholar Science Journals

【 摘 要 】

Background: The physiology of the thyroid gland changes during pregnancy as a result of the effects of increased TBG and hCG levels and enhanced iodine metabolism. These normal hormonal changes can sometimes make thyroid function tests during pregnancy difficult to interpret. Objective: To compare the levels of thyroxine [T4], triiodothyronine [T3], thyrotropin [TSH] and Thyroxine Binding Globulin [TBG] in grand multiparas, nulliparas [control] and primiparas. Materials: A cross-sectional study was performed in 50 non-pregnant ladies as control group, 50 primiparity pregnant women, and 50 grand multiparity pregnant women. All pregnant women were between 10th -14th weeks gestation. Methods: Serum for T4, T3, TSH and TBG were measured by Enzyme-Linked Immunosorbent Assay [ELISA]. Results: When compared to control group, serum levels of T4, T3 and TBG were increased significantly in primiparity and grand multiparity groups, while serum level of TSH was decreased significantly in both groups of pregnant women. Serum level of T4 increased significantly in grand multiparity group comparing to primiparity group. Conclusion: The results suggest that grand multiparity increased the risk of pregnancy-related complication secondary to thyroiddysfunction.

【 授权许可】

CC BY