Spectrophotometric determination of catecholamine using vanadium and eriochrome cyanine r

Quimica nova

Shrestha, Ashwinee Kumar¹  Gowda, Avinask K.¹  Nagaraja, Padmarajaiah¹  Shivakumar, Anantharaman¹  Al-Tayar, Naef Ghallab Saeed¹ 

[1] University of Mysore, Mysore, India

关键词: L-dopa;    methyldopa;    vanadium.;   

DOI  :  10.1590/S0100-40422011000300002

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

A highly sensitivespectrophotometric method for the analysis of catecholamine drugs; L-dopa andmethyldopa, is described. The analysis is based on the reaction of drug moleculeswith vanadium (V) which is reduced to vanadium (IV) and form complex with eriochromecyanine R to give products having maximum absorbance (lmax)at 565 nm. Beer's law is obeyed in the range 0.028-0.84 and 0.099-0.996 mgmL-1 for L-dopa and methyldopa, respectively. The statistical analysisas well as comparison with reported methods demonstrated high precision andaccuracy of the proposed method. The method was successfully applied in theanalysis of pharmaceutical preparations.

【 授权许可】

CC BY