Total syntheses of enokipodins

Quimica nova

Macedo Jr., Fernando¹  Nascimento, Camila B.¹ 

[1] Universidade Estadual de Londrina, Londrina, Brasil

关键词: enokipodins;    quaternary center;    enantioselective synthesis.;   

DOI  :  10.5935/0100-4042.20140157

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Enokipodins comprisesa family of sesquiterpenes isolated from the mushroom Flammulina velutipes.These substances are attractive synthetic targets due to either their biologicalpotential or structural characteristics. Since their isolation, about a decadeago, a considerable number of successful total syntheses have been published.Both via a racemic or enantioselective approach, these studies describe originaland creative synthetic routes, particularly concerning the methodology usedfor constructing the benzylic quaternary center of these natural products. Inthis brief review, we discuss the reported total synthesis of enokipodins, focusingon the strategy adopted for the quaternary stereogenic center.

【 授权许可】

CC BY