Efflux in Fungi: La Pièce de Résistance

PLoS Pathogens

Eleftherios Mylonakis¹  Jeffrey J. Coleman¹ 

[1] Division of Infectious Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

关键词: Antimicrobial resistance;    Fungal pathogens;    Fungi;    Rice blast fungus;    Fungal genomics;    Plant fungal pathogens;    C;    ida albicans;    Secondary metabolites;   

DOI  :  10.1371/journal.ppat.1000486

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Pathogens must be able to overcome both host defenses and antimicrobial treatment in order to successfully infect and maintain colonization of the host. One way fungi accomplish this feat and overcome intercellular toxin accumulation is efflux pumps, in particular ATP-binding cassette transporters and transporters of the major facilitator superfamily. Members of these two superfamilies remove many toxic compounds by coupling transport with ATP hydrolysis or a proton gradient, respectively. Fungal genomes encode a plethora of members of these families of transporters compared to other organisms. In this review we discuss the role these two fungal superfamilies of transporters play in virulence and resistance to antifungal agents. These efflux transporters are responsible not only for export of compounds involved in pathogenesis such as secondary metabolites, but also export of host-derived antimicrobial compounds. In addition, we examine the current knowledge of these transporters in resistance of pathogens to clinically relevant antifungal agents.

【 授权许可】

CC BY