Determination of 5-aminosalicylic acid in pharmaceutical formulations by square wave voltammetry at pencil graphite electrodes

Quimica nova

Yamanaka, Hideko¹  Uliana, Carolina V.¹  Garbellini, Gustavo S.²  Salazar-Banda, Giancarlo R.² 

[1] Universidade Estadual Paulista Júlio de Mesquita Filho, Araraquara, Brasil;Universidade de São Paulo, São Carlos, Brasil

关键词: 5-aminosalicylic acid;    pharmaceutical formulations;    pencil graphite electrode.;   

DOI  :  10.1590/S0100-40422010000400036

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

An analytical methodfor the determination of the anti-inflammatory drug 5-aminosalicylic acid (5-ASA)in pharmaceutical formulations using square wave voltammetry at pencil graphiteelectrodes was developed. After the optimization of the experimental conditions,calibration curves were obtained in the linear concentration range from 9.78× 10-7 to 7.25 × 10-5 mol L-1 resultingin a limit of detection of 2.12 ± 0.05 x 10-8 mol L-1.Statistical tests showed that the concentrations of 5-ASA in commercial tabletsand enemas obtained with the proposed voltammetric method agreed with HPLC valuesat a 95% confidence level.

【 授权许可】

CC BY