Antioxidant, antimicrobial, toxicity and analgesic properties of ethanol extract of Solena amplexicaulis root

Biological research: BR

Saiful Islam¹  Reaz Mohammad Mazumdar¹  Nazim Uddin Ahmed¹  Md Monsor Rahman²  Md Golam Kabir²  Md Fakruddin³ 

[1] Bangladesh Council of Scientific and Industrial Research (BCSIR) Laboratories Chittagong, Chittagong, Bangladesh;Department of Biochemistry and Molecular biology, University of Chittagong, chittagong, Bangladesh;Institute of Food Science Technology (IFST), Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka, Bangladesh

关键词: Solena amplexicaulis;    Antioxidant;    Antimicrobial;    Acute toxicity;   

DOI  :  10.1186/0717-6287-47-36

学科分类：生物科学（综合）

来源: BioMed Central

【 摘 要 】

This study was subjected to investigate different pharmacological properties of ethanol extract of Solena amplexicaulis root. The extract contains flavonoid, alkaloid, saponin and steroid compounds. The extract exhibited excellent antioxidant activity in DPPH radical scavenging activity. The extract also showed potent activity in brine shrimp lethality bioassay. The LC50 value was found to 44.677 μg/ml. The extract showed better anti-bacterial activity against gram-negative bacteria. In antifungal assay, the maximum 79.31% of anti-mycotic activity was observed against Aspergillus ochraceus while minimum 44.2% against Rhizopus oryzae. MIC value ranged between 1500–3000 μg/ml. The extract was found moderately toxic with a 24-hr LD50 value of 81.47 mg/kg in Swiss albino mice. The degree of inhibition by the ethanolic extract of the root was found less than that of standard analgesic drug diclofenac sodium. The extract also showed moderate anti-inflammatory and antinociceptive activity and anti-diabetic property. Reducing power of the extract was comparable with standard ascorbic acid. Moderate in vitro thrombolytic activity, lipid peroxidation inhibition property, metal chelating ability and stress-protective activity was also observed. Ethanol extract of Solena amplexicaulis root can be valuable for treatment of different diseases.

【 授权许可】

CC BY