Relationship of HPVL1 and p16 expression with different cervical lesions

Scientific Research and Essays

Haiying Wu¹ 

关键词:  ;    Cervical tumor;    cervical intraepithelial neoplasia;    human papilloma virus;    HPVL1 protein;    p16.;   

DOI  :  10.5897/SRE11.845

学科分类：社会科学、人文和艺术（综合）

来源: Academic Journals

【 摘 要 】

p16 is a tumor suppressor protein and also a cyclin-dependent kinase inhibitor and HPV-L1 (L1) is a capsidic protein that is expressed in the early, productive phase of cervical carcinogenesis. To provide evidence for the evaluation of endometrial intraepithelial neoplasia (CIN), the expressions ofp16 and HPVL1in different cervical diseases were determined and their relationship was explored. Immunohistochemistry was performed to detect the expressions of p16 and HPVL1in women positive for HPV among whom 38, 32, 28, 33 and 10 had CIN I, CIN II, CIN III, cervical squamous cell carcinoma (SCC) and cervical adenocarcinoma, respectively. Fourteen healthy subjects were recruited as controls. Results showed the positive rate of p16 in cervicitis, CINI, CINII, CINIII,cervical SCC and cervical adenocarcinoma patients was0, 26.3, 81.2, 96.4, 100 and 90%, respectively, and that of HPVL1was 100, 65.8, 13.8, 0, 0 and 0%, respectively. p16(-)/HPVL1(+) was frequently found in patients withcervicitisor cervical lesions of low grade and p16(+)/HPVL1(-) was often noted in women with CINIIIor cervical cancer. The cervical lesions of patients with p16(-)/HPVL1(-) or p16(+)/HPVL1(+) might have no progression or undergo degeneration. Detection of p16 and HPVL1expressions plays an important role in the prediction of early cervical cancer and its progression.

【 授权许可】

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