SYNTHESIS, CHARACTERIZATION, DNA BINDING AND CLEAVAGE ACTIVITY OF RUTHENIUM(II) COMPLEXES WITH HETEROCYCLIC SUBSTITUTED THIOSEMICARBAZONES

Journal of The Chilean Chemical Society

SATHIYARAJ, SUBBAIYAN¹  JAYABALAKRISHNAN, CHINNASAMY¹ 

[1] Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore, India

关键词: Ruthenium(II) complexes;    heterocyclic thiosemicarbazide;    acyl pyrazolone;    DNA-;    interaction.;   

DOI  :  10.4067/S0717-97072013000100029

学科分类：化学（综合）

来源: Sociedad Chilena de Quimica

【 摘 要 】

A new Schiff base ligands (H2L1-H2L3) was synthesized by the condensation reaction of 4-acyl pyrazolones and 2-benzothiazolyl thiosemicarbazide. The ruthenium(II) Schiff base complexes were prepared by the interaction of the ligands with [RuHCl(CO)(EPh3)2(B)] (E=P/As; B=PPh3/AsPh3/py). They were characterized by elemental analysis, IR, UV-vis, 1H, 13C, and 31P NMR spectral data. The interaction of the complexes with CT-DNA has been investigated by electronic absorption spectroscopy technique and the binding mode of the complexes with CT-DNA has been explored. Furthermore, the DNA cleavage activities of the complexes were performed by agarose gel electrophoresis on CT-DNA.

【 授权许可】

Unknown