Preventive activities of Lactobacillus plantarum YS4 in oxazolone-induced BALB/c mice colitis

Journal of RNA i and Gene Silencing

Yu Qian¹ 

关键词: Yu Qian;    Ruokun Yi;    Peng Sun;    Guijie Li;    Xin Zhao;    Lactobacillus plantarum;    Oxazolone;    Colitis;    Chemokine receptor;    Expression;   

DOI  :  

学科分类：生物科学（综合）

来源: Library Publishing Media

【 摘 要 】

The colitis preventive effects of Lactobacillus plantarum YS4 (LP-YS4) were determined by in vitro animal experiment in this study. The BALB/c mice were induced colitis by oxazolone, after inducing colitis, the preventive activities of LP-YS4 were measured using the serum and colon tissue. LP-YS4 (1.83) could significantly reduce (P<0.05) DAI of colitis in mice (3.47) at 25th day, inhibited colitis caused colon shortening and increase ratio of colon weight/length. LP-YS4 also could significantly decrease (p<0.05) the MPO, NO, MDA levels and increase GSH level of colon tissue in mice. Meanwhile, LP-YS4 significantly increased (P<0.05) IL-2 cytokine level and decrease IL-10 level in serum of mice compare to those levels of mice in control group. By RT-PCR assay, LP-YS4 raised nNOS, eNOS, c-Kit, SCF mRNA expressions and reduced iNOS, IL-8, CXCR2 expressions in colon tissue of mice compare to those expressions of mice in control group. From these results, LP-YS4 showed a anti-colitis effect of experimental mice.

【 授权许可】

Unknown