Synthetic approaches to amidines

Quimica nova

Souza, Marcos Costa de¹  Santos, Maurício Silva dos¹  Bernardino, Alice Maria Rolim¹ 

[1] Universidade Federal Fluminense, Niterói, Brasil

关键词: amidine;    synthesis;    methods.;   

DOI  :  10.1590/S0100-40422006000600027

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The amidine functional group is found in a wide range of natural products andis biologically active against several pathogens. In addition, amidines havelong been regarded as useful intermediates in the synthesis of heterocycliccompounds. Consequently, a great number of methods have been developed for thepreparation of amidines. Pinner's method is the most commonly used. Conventionalmethods include: - the addition of metal amides or amines to nitriles, the additionof amines to imido esters and the condensation of amides with amines in thepresence of halogenating reagents. In this report, the main methods for synthesisof amidines will be described.

【 授权许可】

CC BY