Knoevenagel condensation of aromatic aldehydes with Meldrum's acid in water: an experimental class on Green Organic Chemistry

Quimica nova

Cunha, Silvio¹  Santana, Lourenço Luis Botelho de² 

[1] Universidade Federal da Bahia, Salvador;Universidade Federal da Bahia, Salvador, Brasil

关键词: arylidene Meldrum's acid;    undergraduate organic chemistry experiment;    greenchemistry.;   

DOI  :  10.1590/S0100-40422012000300036

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

This work describesan undergraduate experiment for the synthesis of Knoevenagel adduct of Meldrum'sacid with nine aromatic aldehydes, using water as the solvent, in an adaptationof a previously reported synthetic protocol. The synthesis was straightforward,requiring a period of two hours, and is suitable for undergraduate experimentalcourses on green chemistry. In addition, quantitative analyses of the relativereactivity of p-nitro-benzaldehyde and p-metoxi-benzaldehyde wasevaluated through the competitive reaction of equimolar amounts of these aldehydeswith one equivalent of Meldrum's acid, using gas chromatography to quantifythe composition of the reaction mixture.

【 授权许可】

CC BY