High IP‐10 levels decrease T cell function in HIV‐1‐infected individuals on ART

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: CXCL10;    infection;    antiretroviral therapy;    immune responses;    chemokines;   

DOI  :  10.1189/jlb.3A0414-232RR

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

HIV‐1‐infectedsubjects,despitecontrolofviralreplicationwithART,haveanalteredimmunecytokine/chemokinemilieu.Changesinsystemiccytokinesandchemokinescanalterimmuneresponses.IP‐10,inparticular,hasbeenassociatedwithpathogenesisinanumberofconditions,andwefoundthatIP‐10isincreasedinseruminsubjectswhoareHIV‐1infectedandonstableARTcomparedwithHIV‐1‐uninfectedindividuals.Inaseriesofinvitrostudies,wefoundthatPBMCsexposedtoIP‐10showedasignificantdecreaseinthenumberofcellscapableofsecretingIFN‐γ,aswellasothercytokines,whenstimulatedwithrecallantigens.Furthermore,treatmentwithIP‐10ledtodecreasedantigen‐specificcalciumsignalingandMAPK38phosphorylation.Importantly,thecytokines,aswellasproliferativeresponses,couldbeenhancedwithanIP‐10Nab.OurfindingssuggestthatIP‐10‐modulatingdrugsmaypotentiallyenhanceTcellresponsestovaccinationandHIV‐1inHIV+subjectsonART...

【 授权许可】

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