Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
The role of CD200 in immunity to B cell lymphoma | |
关键词: cancer; immune evasion; cancer immunology; | |
DOI : 10.1189/jlb.1009686 | |
学科分类:生理学 | |
来源: Federation of American Societies for Experimental Biology | |
【 摘 要 】
CD200isatransmembraneproteinbroadlyexpressedonavarietyofcelltypes,whichdeliversimmunoregulatorysignalsthroughbindingtoreceptors(CD200Rs)expressedonmonocytes/myeloidcellsandTlymphocytes.SignalsdeliveredthroughtheCD200:CD200Raxishavebeenshowntoplayanimportantroleintheregulationofanti‐tumorimmunity,andoverexpressionofCD200hasbeenreportedinanumberofmalignancies,includingCLL,aswellasoncancerstemcells.WeinvestigatedtheeffectofCD200blockadeinvitroonagenerationofCTLresponsesagainstapoorlyimmunogenicCD200+lymphomacelllineandfreshcellsobtainedfromCLLpatientsusinganti‐CD200mAbandCD200‐specificsiRNAs.SuppressionoffunctionalexpressionofCD200augmentedkillingoftheCD200+cells,aswellasproductionoftheinflammatorycytokinesIFN‐γandTNF‐αbyeffectorPBMCs.KillingwasmediatedbyCD8+cytotoxicTcells,andCD4+TcellsplayanimportantroleinCD200‐mediatedsuppressionofCTLresponses.OurdatasuggestthatCD200blockademayrepresentanovelapproachtoclinicaltreatmentofCLL...
【 授权许可】
CC BY
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201901239899486ZK.pdf | 1016KB | download |