International Journal of Clinical and Experimental Pathology | |
Up-regulation of ROR2 is associated with unfavorable prognosis and tumor progression in cervical cancer | |
Bo Sun1  | |
关键词: Cervical cancer; ROR2; prognosis; progression; | |
DOI : | |
学科分类:生理学与病理学 | |
来源: e-Century Publishing Corporation | |
【 摘 要 】
Aims: To investigate the clinical significance of receptor tyrosine kinase-like orphan receptor 2 (ROR2) in cervical cancer. Methods: We examined ROR2 levels in 8 pairs of surgically resected cervical cancer and adjacent normal cervical tissues by real-time PCR. Moreover, we performed immunohistochemistry to examine ROR2 expression in 94 paraffin-embedded cervical cancer samples and analyzed the association between ROR2 expression, clinicopathologic factors and prognosis. Results: ROR2 expression was up-regulated in cervical cancer tissues compared with adjacent normal cervix. In paraffin-embedded cervical cancer samples, high expression of ROR2 was shown in 40 (42.6%) of 94 cases, also, it was significantly associated with tumor stage (P = 0.018) and lymph nodes metastasis (P = 0.013). Moreover, survival analysis showed that ROR2 expression was an independent prognostic factor of poor overall and recurrent free survival (P = 0.045 and 0.001, respectively). Conclusion: These results indicate that ROR2 is significantly correlated with cancer progression and poor prognosis in cervical cancer.
【 授权许可】
CC BY-NC
【 预 览 】
Files | Size | Format | View |
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RO201901239859498ZK.pdf | 574KB | download |