Tunicamycin Inhibits Diabetes

Cellular Physiology and Biochemistry

关键词: Tunicamycin;    Endoplasmic reticulum stress;    Oxidative stress;    Lymphocytic choriomeningitis virus;    Diabetes;   

DOI  :  10.1159/000338513

学科分类：分子生物学，细胞生物学和基因

来源: S Karger AG

【 摘 要 】

Background Autoimmune diseases are characterized by a breakdown of immunologic tolerance, and this breakdown can lead to life-threatening or lifelong disorders. Moreover; drugs that are used to treat these diseases are few in number and are associated with many serious adverse effects. Methods We used the rat insulin promoter-glycoprotein mouse model to analyze the role of tunicamycin in the process of autoimmune diabetes; the P14 mouse model to analyze the effect of tunicamycin on CD8⁺ T cells; chop knockout mice to analyze the role of tunicamycin on an endoplasmic reticulum stress model; and fluorescence-activated cell sorting, quantitative real-time polymerase chain reaction, and histologic methods. Results We found that a single dose of tunicamycin reduced the activation and pancreatic infiltration of CD8⁺ T cells. This activity delayed the incidence of virus-induced diabetes and improved survival rates. Conclusion Tunicamycin may offer therapeutic opportunities for T cell-mediated autoimmune diseases such as diabetes.

【 授权许可】

CC BY-NC-ND