Synthesis of Tailed Metalloporphyrins Modified with 2‐Chloronicotinic Acid and Interactions with Human Serum Albumin

Bulletin of the Korean Chemical Society

Shu Jun Wang¹  Qi Peng Ma¹  Xiao Xia Peng¹  Li Lei Ren¹  Yu Ling Peng¹  Cheng Gen Zhang¹ 

[1] College of Chemistry and Materials Science Langfang Teachers University Langfang 065000 China

关键词: 2‐;    Chloronicotinic acid;    Zn porphyrin;    Human serum albumin;    Fluorescence quenching;    Thermodynamic parameters;   

DOI  :  10.1002/bkcs.11163

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Two kinds of free‐base tailed porphyrins modified with 2‐chloronicotinic acid and the corresponding Zn porphyrins have been synthesized. They have been characterized by elemental analysis and NMR, UV/Vis, fluorescence spectra, and infrared spectroscopies. Their configurations have been optimized through theoretical calculations. The fluorescence quantum yields were determined by a comparative method. The interactions between the Zn porphyrins and human serum albumin have been studied by means of fluorescence spectra. The experimental results showed that the interaction mechanism involved a combined fluorescence quenching process (static and dynamic quenching) and that the main driving force was hydrophobic in nature. Quenching constants, binding constants, thermodynamic parameters, and binding distances have been determined.

【 授权许可】

Unknown