Rose geranium essential oil as a source of new and safe anti-inflammatory drugs

Libyan journal of medicine

Mohamed Nadjib Boukhatem¹ 

关键词: essential oils;    rose geranium;    citronellol;    anti-inflammatory effect;    skin inflammation;    histopathology;    carrageenan;    croton;   

DOI  :  10.3402/ljm.v8i0.22520

学科分类：医学（综合）

来源: Co-Action Publishing

【 摘 要 】

BackgroundSince the available anti-inflammatory drugs exert an extensive variety of side effects, the search for new anti-inflammatory agents has been a priority of pharmaceutical industries.AimsThe aim of the present study was to assess the anti-inflammatory activities of the essential oil of rose geranium (RGEO).MethodsThe chemical composition of the RGEO was investigated by gas chromatography. The major components were citronellol (29.13%), geraniol (12.62%), and citronellyl formate (8.06%). In the carrageenan-induced paw edema, five different groups were established and RGEO was administered orally in three different doses.ResultsRGEO (100 mg/kg) was able to significantly reduce the paw edema with a comparable effect to that observed with diclofenac, the positive control. In addition, RGEO showed a potent anti-inflammatory activity by topical treatment in the method of croton oil-induced ear edema. When the dose was 5 or 10 µl of RGEO per ear, the inflammation was reduced by 73 and 88%, respectively. ...

【 授权许可】

CC BY