Method validation for the quantification of As, Cd, Hg and Pb in blood by ICP-MS for monitoring purposes

Analytical methods

Francesco Petrucci¹  Costanza Majorani¹  Oreste Senofonte¹  Nicola Violante¹ 

[1] Istituto Superiore di Sanità, Department of Environment and Primary Prevention, Viale Regina Elena 299,Rome,Italy

DOI  :  10.1039/C0AY00429D

学科分类：分析化学

来源: Royal Society of Chemistry

【 摘 要 】

Medical laboratories dedicated to the quantification of trace and ultra trace elements in human biological fluids should be accredited according to the ISO standards 15189 : 2007. The use of validated methods for elements determination in blood becomes crucial for laboratories involved in medical analysis. The toxicological importance of As, Cd, Hg and Pb is well known and internationally recognized. These trace elements may be accumulated in human body through the exposure to pollutants in the environment as a result of uncontrolled anthropogenic activities. The internal levels of these elements can be estimated by the collection of blood samples from groups of selected population (biomonitoring)...

【 授权许可】

CC BY-NC